BioOne.org will be down briefly for maintenance on 17 December 2024 between 18:00-22:00 Pacific Time US. We apologize for any inconvenience.
How to translate text using browser tools
1 April 2003 Photooxidation of 2′-Deoxyguanosine 5′-monophosphate in Aqueous Solution
Lokman Torun, Harry Morrison
Author Affiliations +
Abstract

Mass spectrometric and ultraviolet absorption spectral evidence are presented for the assignment of structures to three products detected in the reaction mixtures formed upon the photolysis of aqueous solutions of the nucleotide 2′-deoxyguanosine 5′-monophosphate (dGMP) with light of wavelengths >270 nm. The products for which structures are assigned are spiroiminodihydantoin 2′-deoxyribonucleotide (1), 2,2-diamino-4-([2-deoxy-5-monophosphate-β-d-erythro-pentofuranosyl]amino)-5-(2H)-oxazolone (oxazolone 2′-deoxyribonucleotide, 2) and 2-amino-5-([2-deoxy-5-monophosphate-β-d-erythro-pentofuranosyl]amino)-4H-imidazol-4-one (imidazolone 2′-deoxyribonucleotide, 3). These results, when combined with mechanistic data presented in an earlier communication, provide support for the proposal that the irradiation of dGMP with UVB light leads to the formation of singlet oxygen. The UV absorption spectral properties of the imidazolone make this product a reasonable candidate to rationalize the autosensitization of dGMP degradation reported in the earlier communication.

Lokman Torun and Harry Morrison "Photooxidation of 2′-Deoxyguanosine 5′-monophosphate in Aqueous Solution," Photochemistry and Photobiology 77(4), 370-375, (1 April 2003). https://doi.org/10.1562/0031-8655(2003)077<0370:PODMIA>2.0.CO;2
Received: 9 October 2002; Accepted: 1 January 2003; Published: 1 April 2003
JOURNAL ARTICLE
6 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

RIGHTS & PERMISSIONS
Get copyright permission
Back to Top